During the 2007–08 season, Messi scored five goals in a week leading Barcelona to the top four in La Liga. On 19 September he scored once as Barcelona defeated Lyon 3–0 at home in a Champions League match.^[44] He scored two goals against Sevilla on 22 September^[45] and then on 26 September, Messi scored another two goals in a 4–1 victory over Real Zaragoza.^[46] On 27 February, Messi played in his 100th official match for Barça against Valencia.^[47]

He was nominated for a FIFPro World XI Player Award under the category of Forward.^[48] A poll conducted in the online edition of the Spanish newspaper Marca had him as the best player in the world with 77 percent of the vote.^[49] Columnists from Barcelona-based newspapers El Mundo Deportivo and Sport stated that the Ballon d'Or should be given to Messi, a view supported by Franz Beckenbauer.^[50] Football personalities such as Francesco Totti have declared that they consider Messi to be one of the current best footballers in the world.^[51]

Messi was sidelined for six weeks following an injury on 4 March when he suffered a muscle tear in his left thigh during a Champions League match against Celtic. It was the fourth time in three seasons that Messi suffered this type of injury.